International Journal of Sustainability

İŞLETMELERDE SÜRDÜRÜLEBİLİRLİĞİN SAĞLANMASINDA LİDER YÖNETİCİLERİN ROLÜ VE UYGULAMA ÖRNEKLERİ

2026-03-12T09:30:30+03:00

This study examines the role of leader-managers in achieving sustainability in business organizations through a conceptual and practice-oriented perspective. Sustainability is discussed not as a temporary managerial trend, but as a strategic necessity associated with long-term organizational survival, resilience, and competitiveness. Building on key sustainability frameworks, the paper reviews how sustainability can be integrated into corporate strategy by emphasizing multi-dimensional performance considerations and stakeholder expectations. The study also highlights the strategic value creation potential of sustainability in terms of risk management, innovation, operational efficiency, and long-term competitive positioning. In the leadership dimension, sustainable leadership is conceptualized through characteristics such as a long-term sustainability-oriented vision, ethical and value-based governance, stakeholder orientation, a high-trust organizational climate, teamwork, and continuous learning and innovation. Overall, the study argues that sustainable outcomes in organizations are strongly shaped by leader-managers’ ability to embed sustainability into strategy and organizational culture in a consistent and measurable manner.

MOLECULAR DOCKING–BASED ANALYSIS AND ANTIBACTERIAL ACTIVITY EVALUATION OF RIFAXIMIN

2026-03-02T12:38:54+03:00

Rifaximin, a semi-synthetic antibiotic derived from the rifamycin group, is particularly common in managing gastrointestinal infections. Due to its low systemic bioavailability, the drug predominantly remains localized in the intestines, allowing it to exert its antibacterial effects while minimizing systemic side effects. Rifaximin works by irreversibly binding to the RNA polymerase enzyme in bacteria, inhibiting its function. In this study, the ligand-receptor complex of rifaximin with the RfaH protein of E. coli was examined using molecular docking methods. Molecular docking simulations were performed using the VINA approach in the YASARA program, and findings regarding the rifaximin-RfaH complex were obtained. The findings provide valuable information on the therapeutic potential of rifaximin in inhibiting E. coli and its possible applications in clinical settings. The compounds antibacterial, antifungal, and antiviral activities were predicted using AntiBac-Pred, AntiFun-Pred, and AntiVir-Pred. Molecular docking models indicate that Rifaximin will have a considerable antibacterial impact, based on its binding affinity of -7.792 kcal/mol to the RfaH protein and its interactions with the target. These data suggest that Rifaximin may be effective against Prevotella disiens (confidence: 0.9715), Bacteroides stercoris (confidence: 0.9685), Clostridium ramosum (confidence: 0.9557), and Porphyromonas asaccharolytica (confidence: 0.9235).

HASTA BİNA SENDROMUNDAN ÇALIŞAN REFAHINA: OFİS TASARIMINDA NÖROBİLİM TEMELLİ YAKLAŞIMLAR

2026-03-12T09:26:55+03:00

This study discusses how office environments influence employee health, wellbeing, and performance by using Sick Building Syndrome as a guiding problem frame and by proposing a neuroscience-informed improvement approach for workplaces. From a neuroarchitecture perspective, an office is evaluated not only through aesthetics and spatial efficiency but also through the neurological and physiological effects of environmental stimuli. The paper reviews key design variables, such as lighting and circadian alignment, noise and acoustic comfort, spatial layout and privacy, the organization of social interaction zones, colour and visual aesthetics, biophilic elements, ergonomics and movement opportunities, as well as indoor air quality and thermal comfort and explains how these factors may relate to stress regulation, attention, cognitive load, creativity, and overall employee wellbeing. The study also highlights that neuroscience-based measurement tools, including EEG, can support evidence-based design by turning intuitive workplace decisions into measurable and comparable interventions. Overall, the paper argues that offices designed with neuroscience guidance can improve employee wellbeing, reduce risks related to absenteeism and performance loss, and contribute to a more resilient organizational culture in the long run.

DETERMINATION OF POTENTIAL MAIN BINDING SITES OF APIXABAN IN P38 MAPK TARGET PROTEIN BY MOLECULAR DOCKING ANALYSIS

2026-03-02T12:38:08+03:00

Apixaban (C₂₅H₂₅N₅O₄), as an anticoagulant has been shown to be superior to warfarin in preventing stroke and systemic embolism and causes significantly less major bleeding based on large randomized trials. In this study, in the first stage, the conformational preferences of Apixaban molecule were examined by conformational analysis, using PM3. The most stable conformer of the Apixaban, which has the lowest energy among all possible conformations, was used as initial data in molecular docking analysis of the molecule into the target protein. Since p38 Mitogen-activated protein kinase protein (p38 MAPK) is an important player in the post-ischemic myocardial apoptotic signal transduction pathway, the interaction mechanisms of Apixaban docked into the p38 MAPK target protein were investigated. The interacting amino acid residues of the target protein with Apixaban, interaction modes, as well as the binding affinity were calculated.

PUBLIC RELATIONS AND SUSTAINABILITY RELATIONSHIP: A CONCEPTUAL ANALYSIS FROM THE PERSPECTIVE OF STAKEHOLDER EXPECTATIONS

2026-03-09T19:13:39+03:00

This study examines the mechanisms through which stakeholder expectations shape corporate actions and discourses in the field of sustainability and analyzes how public relations measure, prioritize, and institutionalize these expectations within the axes of ethics, trust, and transparency. The study integrates the normative, instrumental, and descriptive dimensions of stakeholder theory with legitimacy theory and institutional isomorphism. Drawing on theoretical analysis and case examples, findings indicate that stakeholder expectations influence sustainability communication through materiality processes, dialogue design, and evidence-transparency architecture. Sustainability communication is therefore not merely an informational practice it is a structural component of corporate legitimacy production and governance mechanisms. The risk of greenwashing emerges when inconsistencies arise between communication and performance, leading to legitimacy erosion. The study conceptualizes sustainability communication as a multilayered governance practice positioned between normative responsibility and strategic rationality.